Search results for "Parkinsonâ s disease"

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Effects of More-Affected vs. Less-Affected Motor Cortex tDCS in Parkinson’s Disease

2017

Objective. To evaluate therapeutic potential of different montages of transcranial direct current stimulation (tDCS) in Parkinson’s Disease (PD) patients with asymmetric motor symptoms. Materials and Methods. Fourteen patients with asymmetric PD underwent, while on treatment, seven separate sessions including electrophysiological and clinical evaluation at baseline and after anodal, cathodal and sham tDCS of the primary motor cortex (M1) of the two hemispheres. Changes in motor cortical excitability were evaluated by transcranial magnetic stimulation. Effects on motor symptoms were assessed by testing finger tapping and upper limb bradykinesia, and by using the Italian validated Movement Di…

0301 basic medicinemedicine.medical_specialtynon-invasive brain stimulationParkinson's diseaseNeurologymedicine.medical_treatmenttDCSlcsh:RC321-57103 medical and health sciencesBehavioral Neuroscience0302 clinical medicinePhysical medicine and rehabilitationmotor cortexmedicineParkinsonâ s diseaselcsh:Neurosciences. Biological psychiatry. NeuropsychiatryBiological PsychiatryOriginal ResearchTranscranial direct-current stimulationcortical excitabilitymedicine.diseaseTranscranial magnetic stimulationElectrophysiology030104 developmental biologymedicine.anatomical_structureNeuropsychology and Physiological PsychologyNeurologyPsychiatry and Mental HealthFinger tappingParkinson’s diseaseSettore MED/26 - NeurologiaPrimary motor cortexPsychologyNeuroscience030217 neurology & neurosurgeryMotor cortexCortical excitability; Motor cortex; Non-invasive brain stimulation; Parkinson’s disease; tDCS; Neuropsychology and Physiological Psychology; Neurology; Psychiatry and Mental Health; Biological Psychiatry; Behavioral NeuroscienceNeuroscienceFrontiers in Human Neuroscience
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Mild cognitive impairment in Parkinson’s disease: the Parkinson’s disease cognitive study (PACOS)

2018

Approximately 30% of Parkinson's disease (PD) patients show impaired cognitive performance, which is suggestive of Mild Cognitive Impairment (MCI), representing a predictor of dementia, especially when present at diagnosis. The objective of the study was to evaluate the frequency and clinical predictors of MCI in a large hospital-based cohort of PD patients. We collected cross-sectional data from the Parkinson's disease cognitive impairment study (PACOS), a multicenter study involving two Movement Disorder centers, which are located in south Italy. The PD subjects were diagnosed according to the UK Brain Bank criteria and they underwent an extensive neuropsychological assessment. PD-MCI was…

Male0301 basic medicinemedicine.medical_specialtyNeurologyParkinson's diseaseEpidemiologyParkinson's diseaseNeuropsychological TestsLogistic regressionSeverity of Illness Index03 medical and health sciences0302 clinical medicineInternal medicinemental disordersEpidemiologyOdds RatioPrevalenceHumansMedicineDementiaCognitive DysfunctionParkinsonâ s diseaseEffects of sleep deprivation on cognitive performanceNeuropsychological assessmentAge of OnsetCognitive impairment; Epidemiology; Parkinson’s disease; Prevalence; Neurology; Neurology (clinical)AgedRetrospective Studiesmedicine.diagnostic_testbusiness.industryParkinson Diseasemedicine.diseasenervous system diseasesCross-Sectional StudiesCognitive impairment030104 developmental biologyNeurologyMultivariate AnalysisCohortEducational StatusSettore MED/26 - NeurologiaFemaleAmnesiaNeurology (clinical)businesshuman activities030217 neurology & neurosurgeryJournal of Neurology
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